Central Neurotransmitter Turnover

Neurotransmitter Release at Central Synapses

Our understanding of synaptic transmission has grown dramatically during the 15 years since the first issue of Neuron was published, a growth rate expected from the rapid progress in modern biology. As in all of biology, new techniques have led to major advances in the cell and molecular biology of synapses, and the subject has evolved in ways (like the production of genetically engineered mice...

Adenosine decreases neurotransmitter release at central synapses.

Adenosine, at concentrations ranging from 5 to 100 microM, decreases the efficacy of transmission at the perforant path synapses on dentate granule cells. We have used whole cell recording from these cells in slices to determine the mechanism of the reduced synaptic strength. We find that size of miniature excitatory postsynaptic currents (mepscs) is unaffected by adenosine at concentrations up...

Neurotransmitter transporters in the central nervous system.

Central Dopamine and Serotonin Turnover in Schizophrenia

Comparison of C.S. F. H. V. A and 5-HIAA levels of 20 Schizophrenics and 9 non-schizophrenic controls revealed no statistically significant difference between HVA levels but the 5-HIAA levels were significantly less in Schizophrenics (p < 0.05) than in controls. The significance of these findings is discussed.

Central neurotransmitter function and its behavioral correlates in man.

The past decade has witnessed a tremendous increase in knowledge towards understanding the function of various brain neurotransmitter substances in behavior. Experimental observations in animals, utilizing specific pharmacological agents, have enabled the development of certain hypotheses regarding neurochemical substrates of behavior. These have led to cautious applications of complementary st...